Researchers have developed a new treatment for Alzheimer’s disease by injecting nanoparticles that can trap misfolded proteins, preventing them from forming toxic plaques. The tiny particles, designed to combine with both fat and water, bind to amyloid beta proteins, protecting tissue from damage.
The treatment uses peptide amphiphile compounds, which are also used in other medications like semaglutide (Ozempic), along with trehalose, a naturally occurring sugar that helps prevent protein misfolding. When combined, the nanoparticles and trehalose create a framework where amyloid beta proteins can’t cause harm.
This approach aims to target misfolded proteins at an early stage, before they form destructive fibers that are highly toxic to neurons. The researchers believe this could significantly delay disease progression.
The study’s lead authors say their work highlights the potential of molecularly engineered nanomaterials to address the root causes of neurodegenerative diseases like Alzheimer’s and dementia. With over 10 million new diagnoses expected each year, innovative treatments are desperately needed.
Source: https://www.sciencealert.com/sugar-coated-particles-may-protect-neurons-from-alzheimers-disease