Stephen Hauser, a renowned neuro-immunologist, has received the 2025 Breakthrough Prize in Life Sciences for his groundbreaking work on multiple sclerosis (MS). Hauser’s pioneering research identified B cells as the primary driver of damage to nerve cells in MS patients. His discoveries have revolutionized modern treatment of the disease, leading to therapies that have reduced relapses, halted or delayed disability progression, and decreased lesions.
Hauser was recognized along with Alberto Ascherio, who discovered that contracting the Epstein-Barr virus increases the risk of developing MS by a factor of 32. The Breakthrough Prize is awarded annually to scientists in life sciences, physics, and mathematics, with prizes of $3 million. Hauser’s award acknowledges his dogged determination in overcoming obstacles to develop B-cell therapies, which have transformed treatment for MS patients.
Hauser’s work has had a profound impact on the disease, with many new patients now expected to live free from disability. He attributes this success to the collaboration between laboratory and clinical researchers, as well as industry leaders and private funders. Hauser believes that future research will continue to benefit more patients, particularly those with progressive MS whose response to B-cell therapies is muted.
A 2023 memoir by Hauser recounts a life-changing encounter with a young woman suffering from MS, which sparked his resolve to make the disease his life’s work. Throughout his career, Hauser has faced setbacks but remained committed to his research, leading to “eureka moments” that challenged expert wisdom. His latest award is a testament to his dedication and perseverance in advancing our understanding of MS and developing effective treatments.
Source: https://www.ucsf.edu/news/2025/04/429746/stephen-hauser-wins-breakthrough-prize-role-redefining-ms