A clinical trial led by a cardiologist from the Cleveland Clinic has found that a new type of blood pressure medication called lorundrostat significantly decreased blood pressure in patients with uncontrolled hypertension. The study, which included 285 participants at 103 sites across the US, used 24-hour ambulatory blood pressure monitoring to assess the drug’s efficacy.
The results showed that those taking the 50mg daily dose of lorundrostat saw a decrease of 15.4 blood pressure points compared to placebo, while the 50-100mg group saw an average drop of 13.9 points. The study’s lead author, Luke Laffin, MD, emphasized the importance of using this type of monitoring to assess a drug’s effects on blood pressure.
High blood pressure, or hypertension, occurs when the force of blood pushing against artery walls is consistently too high. Uncontrolled or resistant hypertension poses a higher risk of complications such as heart attack and stroke. Lorundrostat was developed to address abnormal aldosterone levels, which contribute to high blood pressure.
The study’s findings are encouraging for clinicians looking for new, safe, and effective medications to treat patients with uncontrolled hypertension. The trial is part of a larger effort to develop lorundrostat, which has shown promise in earlier trials.
Source: https://newsroom.clevelandclinic.org/2025/03/29/clinical-trial-shows-novel-drug-safely-and-significantly-treats-uncontrolled-hypertension