A recent study by Scripps Research Institute has found that a single genetic mutation in the highly pathogenic influenza (HPAI) H5N1 virus may enable it to attach more easily to human cells, potentially facilitating person-to-person spread. However, multiple mutations are likely required for the virus to exclusively bind to human cell receptors and transmit efficiently among humans.
Source: https://www.cidrap.umn.edu/influenza-general/under-certain-conditions-single-h5n1-flu-virus-mutation-could-lead-spread-among