Diabetes is a growing global health concern, and its complications, particularly chronic wounds, can be debilitating and costly. Researchers have been searching for a material that can simultaneously target infection, inflammation, and high blood sugar levels to address the root causes of delayed healing.
A new study published in Burns & Trauma presents a breakthrough approach to managing chronic diabetic wounds. Scientists have developed a multifunctional hydrogel called DPFI that accelerates wound healing while regulating blood glucose levels. The hydrogel integrates dihydromyricetin, which targets key aspects of diabetic wound care.
The DPFI hydrogel delivers multiple therapeutic benefits through a controlled release system. It has antimicrobial properties effective against MRSA and E. coli, reduces oxidative stress, modulates macrophage polarization to reduce inflammation, and promotes angiogenesis to form new blood vessels crucial for healing. In vivo experiments in diabetic mice demonstrated significant acceleration of wound healing, reduced infection, and improved blood glucose control.
This breakthrough hydrogel represents a major advancement in treating complex diabetic wounds. By addressing multiple facets of wound healing, it offers a holistic solution that tackles the multifactorial challenges of delayed wound recovery. Further clinical trials are needed to confirm its long-term safety and efficacy, but early results show promising hope for millions of diabetic patients worldwide.
Source: https://www.news-medical.net/news/20250807/Multifunctional-hydrogel-offers-new-hope-for-diabetic-wound-healing.aspx