A recent study published in Science has found that a single alteration in the protein on the surface of the H5N1 avian influenza virus could significantly increase its ability to transmit between humans. The study, funded by the National Institutes of Health (NIH), suggests that genetic changes in the virus’s hemagglutinin protein could allow it to bind to human cells more effectively.
The researchers found that a mutation called Q226L improved the virus’s binding capabilities when paired with another mutation. However, it is essential to note that this single mutation does not guarantee widespread transmission among humans. The authors emphasize the importance of ongoing surveillance and monitoring to track genetic changes that could enhance transmissibility.
It is crucial to understand that currently, the bovine H5N1 virus is not capable of human-to-human transmission. However, infections have been documented in individuals exposed to infected wild birds, poultry, or other mammals. The study highlights the need for continued research and monitoring to prepare for potential pandemic scenarios.
The NIH’s National Institute of Allergy and Infectious Diseases has funded this research as part of its efforts to track natural genetic mutations and assess their impact on transmissibility. This is in line with global pandemic preparedness efforts.
Source: https://scitechdaily.com/alarming-mutation-in-h5n1-virus-raises-pandemic-red-flags