Lung cancer cases are increasing among women who have never smoked, according to a new study by the World Health Organization’s cancer agency. The study, published in The Lancet Respiratory Medicine, reveals that lung adenocarcinoma, the most common type of lung cancer among non-smokers, accounts for nearly 60% of lung cancer cases in women compared to 45% in men.
The study found that environmental factors, particularly air pollution, along with genetic predisposition and immune responses, may be driving this rise in non-smoking-related lung cancer. Genetic mutations, such as those in the EGFR gene, are a significant risk factor for lung cancer in non-smokers.
Women are more likely to develop autoimmune diseases than men, which can lead to chronic inflammation and increase the risk of lung cancer. Air pollution, hormone fluctuations, and immune system imbalances also contribute to this rise. The study suggests that exposure to air pollution, particularly PM2.5 particles, may trigger these genetic mutations.
The findings highlight the need for further research into the causes of non-smoking-related lung cancer in women. Understanding the roles of immune, hormonal, genetic, and viral factors is crucial in spotting lung cancer early, creating more effective treatments, and developing better prevention strategies.
Source: https://theconversation.com/why-is-there-an-increase-in-lung-cancer-among-women-who-have-never-smoked-249406