A recent study reveals that the microbial ecosystems in our mouths could play a significant role in cognitive function as we age. Interventions like prebiotics, particularly those containing dietary nitrate, may help delay cognitive decline in older adults. About 15% of older adults experience mild cognitive impairment (MCI), which is the primary risk factor for developing dementia or Alzheimer’s disease. Researchers discovered a connection between periodontitis (gum disease) and reduced cognitive function. They hypothesize that oral bacteria might enter the bloodstream, affecting brain health, or displace nitrate-reducing bacteria, crucial for creating nitric oxide in the brain.
The study analyzed the oral microbiome of 115 participants, half of whom had MCI. Those with higher Neisseria abundance showed better executive function and visual attention, while Porphyromonas was linked to cognitive impairment severity. APOE4 carriers (a genetic risk factor for cognitive decline) correlated with Prevotella intermedia presence. Diet plays a role in shaping the microbiome; nitrate-rich diets (e.g., Mediterranean or KDASH diet) are associated with beneficial bacteria linked to good cognitive outcomes. This research highlights how gut health may impact brain function and aging-related cognitive issues.
Source: https://www.news-medical.net/news/20250128/Study-links-oral-microbiome-to-cognitive-function-in-older-adults.aspx