A breakthrough in understanding the connection between gut microbiota and blood pressure could lead to new treatments for hypertension. Dr. Bina Joe, Distinguished University Professor at The University of Toledo, is leading a research team that aims to find novel ways to lower blood pressure by targeting the gut-liver axis.
The study focuses on how microbes in the gut contribute to elevated blood pressure. According to Dr. Joe, “We’re shifting our thinking from treating just the body to resetting the ecosystem within us.” Her lab has made significant progress in understanding the link between gut bacteria and blood pressure regulation.
Previous research by Dr. Joe’s team revealed that engineered bacteria can lower blood pressure, while another study showed that certain gut bacteria can lessen the effectiveness of existing blood pressure medication. The latest project, funded by a $4 million grant from the National Heart, Lung and Blood Institute, investigates how bacterial-driven changes to bile acids in the gut affect blood pressure.
The researchers discovered that higher populations of a particular bacterium are associated with elevated blood pressure and that feeding hypertensive animal models taurine or taurocholic acid supplements can reduce blood pressure. By identifying the specific gut bacteria involved, Dr. Joe’s team hopes to develop new treatments that target the gut-liver axis.
Currently, most blood pressure medications focus on targeting the brain, heart, or kidneys. However, if successful, this new treatment could help 10% to 20% of patients who remain uncontrolled despite aggressive measures. As Dr. Joe notes, “We’re inching closer to completely novel ways of treating hypertension.”
The research has sparked hope for a more personalized approach to managing blood pressure and improving cardiovascular health. With further investigation, this breakthrough could lead to innovative treatments that prioritize the gut-liver axis.
Source: https://www.toledoblade.com/b-partners/utmc/2025/01/13/the-power-to-do-groundbreaking-hypertension-research(copy)/stories/20250113084