UC San Diego researchers have identified an enzyme, N4BP2, that drives chromothripsis, a phenomenon in which a single chromosome breaks apart and is stitched back together in a disordered way. This extreme genetic disruption allows cancer cells to adapt quickly and develop resistance to therapy. By understanding the mechanism behind chromothripsis, scientists hope to develop new therapies for aggressive tumors.
Source: https://scitechdaily.com/scientists-solve-a-decade-old-mystery-behind-cancers-most-violent-dna-chaos