A team of researchers has made a groundbreaking discovery that could revolutionize the way drugs are delivered over long periods. A new contraceptive implant that self-assembles in the body using micro-crystals of synthetic progesterone could bring benefits beyond birth control, offering a simple and non-invasive way to administer long-acting drug delivery systems.
The current method for creating long-lasting contraceptives involves surgical procedures, which can be expensive and inaccessible in many parts of the world. Contraceptive injections are also available but have limitations, including short duration and higher costs. The new approach, on the other hand, uses a solvent that exchanges with bodily fluids, resulting in the formation of solid crystals that release drugs slowly over time.
The researchers tested their method in rats and achieved sustained drug release for at least 97 days. However, more work is needed to confirm its efficacy and safety. The team plans to conduct human trials within the next three to five years and hopes to make the technology accessible to individuals in low-resource settings.
Experts praise the innovation, citing its potential to provide a convenient option for people with limited access to healthcare services. Dr. Giovanni Traverso, one of the researchers, said that the approach is compatible with multi-year dosing and can be easily removed if needed. The development of this technology has the potential to bring significant benefits beyond reproductive health, including treatments for HIV, tuberculosis, schizophrenia, chronic pain, and metabolic disease.
Source: https://www.theguardian.com/society/2025/mar/24/scientists-develop-injection-for-long-lasting-contraceptive-implant