A groundbreaking study by a South Korean research team may hold the key to restoring lost vision in humans. The researchers have found a way to trigger nerve cell regeneration in the retina using antibodies that block a protein called Prox1, which hinders retinal nerves from regenerating.
In mice experiments, the treatment successfully stimulated the growth of new retinal cells, offering hope for individuals with degenerative retinal diseases such as retinitis pigmentosa and glaucoma. The study’s findings suggest that by blocking Prox1, retinal nerve support cells called Müller glia can reprogram into retinal progenitor cells, promoting regeneration.
The research has shown promising results, with the effects of Prox1 blockage lasting for six months or longer in mice models. While more work is needed before human trials can begin, the study’s implications are significant. According to Eun Jung Lee, biologist at Korea Advanced Institute of Science and Technology, the goal is to provide a solution for patients at risk of blindness who currently lack proper treatment options.
The discovery links with other research investigating ways to repair eye damage, including laser-activated retinal cells and stem cell transplants. With hundreds of millions of people worldwide affected by degenerative retinal diseases, this breakthrough could have a profound impact on maintaining quality of life into old age. Clinical trials may begin as early as 2028.
Source: https://www.sciencealert.com/experimental-drug-tested-in-mice-repairs-the-eye-to-restore-vision