Imagine cells as electronic devices that need energy from batteries – mitochondria – to function. Over time, these batteries wear out and lose their power, causing cells to malfunction. Researchers have created a method to regenerate mitochondria, which could lead to new treatments for degenerative diseases.
Mitochondrial dysfunction is linked to many diseases, including neurodegenerative disorders, cardiovascular disease, and metabolic disorders. Current methods to replace dead batteries are inefficient. To address this, biomedical engineer Akhilesh Gaharwar developed a way to transfer mitochondria from healthy stem cells to damaged ones using nanostructures called nanoflowers.
Nanoflowers were created with molybdenum disulfide and are designed to encourage the formation of new mitochondria in stem cells. When these cells were introduced to damaged ones, they rejuvenated them by transferring their batteries. This breakthrough has promise for future treatments.
The researchers also explored the benefits of mitochondrial transfer beyond cellular energy levels. They found that smooth muscle cells could be supercharged with new batteries, leading to enhanced vascular contraction and control of blood pressure. While this method is still in its early stages, it holds potential as a therapeutic tool for managing mitochondrial dysfunction in diseases like Parkinson’s or Alzheimer’s.
Gaharwar plans to conduct future animal studies before testing the method on humans. Early-stage degenerative disease patients may see benefits from this treatment. The researchers’ approach uses nanomaterials to enhance mitochondrial transfer and promote biogenesis, offering a promising solution for managing mitochondrial dysfunction.
Source: https://www.popularmechanics.com/science/health/a69587645/recharging-cells