A breakthrough in medical technology is transforming disease treatment with mRNA-based vaccines and therapeutics. However, producing high-quality mRNA requires a reliable workflow.
Scientists need a straightforward process to create capped mRNA, which must be delivered safely and effectively into the body. To address this challenge, researchers have developed an optimized mRNA synthesis kit that streamlines production while maintaining quality.
Two key structures, Cap 1 and Cap 0, are used in mRNA synthesis. The main difference between them lies in their functionality, with Cap 1 providing a more stable structure for efficient delivery.
Modifying mRNA also plays a crucial role in improving therapy outcomes. Removing double-stranded RNA by-products enhances the therapeutic potential of mRNA-based treatments.
In vivo testing has shown that synthesized mRNA delivered via lipid nanoparticles exhibits excellent performance. The optimized synthesis kit enables researchers to produce high-quality mRNA, paving the way for more effective and targeted disease prevention and treatment strategies.
Source: https://www.the-scientist.com/generating-high-quality-mrna-for-in-vivo-delivery-72547