Biohackers and celebrities alike have turned their attention to NAD+, a molecule that plays a critical role in energy production, DNA repair, and cell survival. But is it the “holy grail” of supplements?
NAD+ stands for nicotinamide adenine dinucleotide, and its active form has been found to slow aging, boost brain health, and increase disease resilience. However, levels naturally decline with age, making NAD+ tests, supplements, and infusions a growing industry.
The molecule is essential for activating enzymes called sirtuins and PARPs, which are involved in DNA repair, longevity, and inflammation. It’s also crucial for producing cellular energy in the form of ATP, or “cellular gasoline.” When NAD levels are low, mitochondria don’t function efficiently, leading to decreased ATP production and increased oxidative stress.
While tryptophan, a protein product found in foods like red meat and dairy, is one of our two big sources of NAD+, supplements are another route. However, the tablets are poorly absorbed by the body, making precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) more effective.
Research suggests that NAD+ levels can decrease with age, but this process isn’t well understood. Symptoms of deficiency include fatigue, neurological decline, and brain fog. Testing for NAD+ levels is recommended to determine if supplementation is necessary, but at-home kits are not reliable due to the lack of universal consensus on what constitutes “high,” “adequate,” or “low” NAD+ levels.
Boosting NAD+ levels can be done through various methods, including capsules, IVs, nasal sprays, and topical creams. However, more research is needed to assess the capacity of these methods to positively impact overall health. Some enthusiasts swear by oral supplementation, while others prefer IV therapy or combination regimens.
While NAD+ holds promise for longevity, it’s essential to note that there’s no single “magic pill” that can solve all health woes. A balanced lifestyle, including weight training, better nutrition, and inflammation reduction, is still the best approach. As with any supplement, a healthy dose of skepticism is necessary when considering NAD+.
Source: https://nypost.com/2025/05/01/health/nad-supplements-are-beloved-by-biohackers-celebs-do-they-work