At 82, Carol Siegler is living proof that some people can resist the effects of aging on their brains. Known as “SuperAgers,” these individuals possess a brain that stays sharp and healthy well into old age. Researchers at Northwestern University’s SuperAging Program have been studying this phenomenon for over two decades, uncovering fascinating insights into the human brain.
To be considered a SuperAger, an individual must undergo extensive cognitive testing and demonstrate exceptional episodic memory, which is essential for recalling everyday events and past experiences. Studies have shown that these individuals tend to be highly social, valuing connection and community involvement, and possessing a strong sense of autonomy and independence.
But what sets their brains apart? Research has revealed that SuperAgers have a thicker cingulate cortex, an area responsible for attention, motivation, and cognitive engagement. They also have fewer tau tangles in the hippocampus, the memory center of the brain, which is often associated with Alzheimer’s disease.
Moreover, SuperAger brains exhibit remarkable structural integrity, with larger and healthier cells in the entorhinal cortex, an essential area for memory and learning. This is likely due to a stronger immune system, which responds efficiently to clear out disease and toxins without overreacting.
While genetics play a role in protecting the brain against aging, research suggests that environmental factors also contribute to this phenomenon. By understanding the complex interplay between internal and external environments, scientists hope to develop personalized prevention or treatment strategies for Alzheimer’s disease.
For now, SuperAgers like Carol Siegler continue to inspire researchers, reminding us that a healthy brain is capable of incredible feats well into old age.
Source: https://edition.cnn.com/2025/08/07/health/superager-brain-research-wellness