Scientists have discovered evidence in mice that xenon gas might help treat Alzheimer’s disease. A new study published this week in Science Translational Medicine found that inhaling xenon reduced inflammation and brain shrinkage in mice with Alzheimer’s-like symptoms. The researchers, from Brigham and Women’s Hospital and Washington University, are now planning early human trials to test the therapy’s potential.
Xenon gas is already used as an anesthetic and medical imaging agent, and research has suggested it could protect the brain and even treat depression. However, its ability to pass through the blood-brain barrier makes it a promising candidate for treating Alzheimer’s. The study found that inhaling xenon activated the brain’s immune cells, called microglia, which helped to fend off damaging changes associated with the disease.
While the findings are based on mice, they are compelling enough for the researchers to proceed with human trials. A Phase I trial is set to launch in the coming months to test the safety and immune effects of xenon gas on healthy subjects. If successful, this discovery could pave the way for new possibilities in harnessing xenon’s potential for brain healing.
Currently, around 7 million Americans live with Alzheimer’s, a number expected to nearly double by 2050. New therapies that can slow or halt disease progression are urgently needed.
Source: https://gizmodo.com/this-anesthesia-gas-could-be-the-next-big-alzheimers-treatment-2000551153